PREDICTING THE EFFECTS OF CYP2C19 AND CARBOXYLESTERASES ON VICAGREL, A NOVEL P2Y12 ANTAGONIST, BY PHYSIOLOGICALLY BASED PHARMACOKINETIC/PHARMACODYNAMIC MODELING APPROACH

Vicagrel, a novel acetate derivative of clopidogrel, exhibits a favorable safety profile and excellent antiplatelet activity.Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes here Cytochrome P450 2C19 (CYP2C19), Carboxylesterase (CES) 1 and 2 (CES1 and CES2), which may potentially lead to altered pharma

Random chemical mutagenesis of the mouse genome can causally connect genes to specific phenotypes.Using this approach, reduced pinna (rep) or microtia, a defect in ear development, was mapped to a small region of mouse chromosome 2.Sequencing argan oil pure purple of this region established co-segregation of the phenotype (rep) with a mutation in t

The analysis of a number of problems of the investigation of the electoral process viewed as a social phenomenon contributes to the overcoming of a number of theoretical and methodological obstacles in the process of its sociological cognition.The complexity and delicacy of the electoral process entails the application of a set of distinct approach